Capo on 3 - These chords work ok for this Biochemistry-ised version of the Welsh battle song.
[Verse 1]
If you gobble tagliatelli,
Chicken soup with vermcilli,
Youâll acquire a sagging belly â
Whatâs the use of that?
[Verse 2]
If your intakeâs calorific,
Guzzling beer till soporific,
Possibly youâll feel terrific,
But youâll end up fat.
[Refrain 1]
Fat against starvation;
Fat for insulation;
If you sit hard youâll bounce on lard
Which substitutes in females for inflation.
Fat provides when you are needing
Glucogenic when youâre seeding
Product of excessive feeding
Hail Adipocyte!
[Verse 3]
That cell does not believe in spurning
Excess food that it s not burning.
Therefore carboyhdrate turning
To an acetyl
[Verse 4]
Trapped inside the matrix spaces
CoA esters in such places
Need to show some fancy paces
And a dash of style
[Refrain 2]
Hence, citrate formation,
Anion translocation
(The other way, goes malate,say)
And cleavage then reverses condensation
Acetyl CoA formation
Outside ready for ligation
Now forms by carboxylation
Malonyl CoA.
[Verse 5]
Fatty acid synthetase is
So complex that it amazes
By the subtle interphases
Between every piece.
[Verse 6]
Twice we find a thiol centre
Through which all new carbons enter
Structured so as to prevent a
Premature release
[Refrain 3]
First one on the scene I ll
Say is pantothenyl
On ACP, as we shall see,
A carrier of acyl groups, but meanwhile
There s an outer thiol station
Much involved in condensation
Starts off with an acylation
By an acetyl.
[Verse 7]
Firstly, now that s all been stated
A-P-Cs malonylated,
Which of course is integrated
With CoA release.
[Verse 8]
Now there is a new ligation
Paid by decarboxylation
Acetyl from outer station
Makes a C4 piece.
[Refrain 3]
Really it s quite neat, oh!
Nature doesn t veto
What we ve just seen, on methylene
Gives ACP with acyl Beta keto,
A-C-P now acts as hinging,
Keto acyl is now swinging
Till its keto group it s bringing
To the reductase.
[Verse 9]
If when we re metabolising
It s for biosynthesising
N-A-D-P-H arising
Has a ready use.
[Verse 10]
Pentose phosphate H-extraction,
Also malic enzyme action,
All in cytosolic fraction,
All set to reduce
[Refrain 4]
Keto group reduction,
Hydroxy construction
On A-C-P, so never free,
Hydroxy Beta butyryl production,
Next we swing to dehydration,
Enoyl A-C-P formation,
Then a new hydrogenation
Saturates the chain.
[Verse 11]
Acyl fate is now transferal
To free thiols peripheral,
Pantothenyls thus prepare all,
For the next attack,
[Verse 12]
As in circuit we ve just ended
Malonyl is apprehended,
A-C-P again appended,
C4 now passed back,
[Refrain 5]
Bicarb, generating,
C6 thus creating,
Again we ve got, on Beta spot,
A keto in the chain we re saturating,
That s reduced, then dehydrated,
Double bond eliminated,
Now repeat, till we ve created
Palmitoyl CoA!